Which would you find emotionally easier:
having someone occupy your home while you are away for an extended period of time or having someone occupy your office?
This question assumes that you have an office that has been 'yours' for long enough for you to have settled in (quite) a bit. And it is more of a real choice if you don't hate your office (or home).
My answer is: home.
I love my house, but I don't mind having house-sitters, even ones I don't know. Preparing our house to be occupied by others is the only time we really clean it, and it's good to do that every once in a while. The prospect of making my office habitable for another human being is, however, more than I can imagine, so I'd rather not think about it (much less do it).